Survival among cancers screened at the first stage of Dispanserization of certain groups of the adult population: a population-based epidemiological analysis

Objective: to evaluate trends of survival in nine index malignant neoplasms (iMNs), which are screened at the first stage Dispanserization certain groups adult population (DCGAP), on data Arkhangelsk regional cancer registry over a period 2006-2019.
 Materials and methods. We compared two seven-year periods 2006-2012 2013-2019, before after introduction DCGAP. The 1- 5-year cancer-specific (CSS) rate was calculated using life table Kaplan-Meier methods with an assessment differences by log-rank. Cox regression analysis sequential input used identify possible causes between independent prognostic factors.
 Results. 37197 cases were selected for analysis. CSS estimates 2013-2019 previous significantly increased all iMNs, from 2.5% [2006-2012, 12.5% ​​(95% confidence interval (CI) 11.4-13.6%) vs 15.0 (95% CI 13.7-16.5%)] lung up 12.6% 31.0% 28.6-33.4%) 43.6 40.8-46.2%)]. Correction (possible effect screening) model has led decrease hazard ratio (HR) death colon, rectum, breast, kidney 38-64%, no change other iMNs; while cervical cancer, it increased. Adjustment variable "treatment method" 34-100% HR except prostate cancer.
 Conclusion. increase iMNs can be explained large extent improved access cancer-directed treatment its quality; contribution DCGAP is renal, breast colorectal Key words: neoplasms, screening, dispensarization population,